Hydrochloric Acid → HCID 23078254, compound

Participants

Reaction Steps

5-Fluoro-1H-indole-2,3-dione (1.19 g) and 2-hydroxy-1-phenyl-ethanone (2.25 g) were dissolved in methanol (70 ml) to prepare a solution. Sodium hydroxide (4.82 g) and water (30 ml) were added to the solution, and the mixture was stirred at room temperature overnight. Dilute hydrochloric acid was added to the reaction solution, and the precipitated crystal was washed with methanol and water to give 6-fluoro-3-hydroxy-2-phenyl-quinoline-4-carboxylic acid (427 mg, yield 21%).

Provenance & Evidence