Benzyl isocyanate → HCID 18699950, compound

HRID 2288609Notes

Reaction equation

HRID 2288609 reaction equation
[CH2:1]([N:8]=[C:9]=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:11][C:12]1[O:16][C:15]([C:17]2[S:21][C:20]([CH2:22][N:23]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)=[CH:19][CH:18]=2)=[N:14][N:13]=1>N1C=CC=CC=1>[CH2:1]([NH:8][C:9]([NH:11][C:12]1[O:16][C:15]([C:17]2[S:21][C:20]([CH2:22][N:23]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)=[CH:19][CH:18]=2)=[N:14][N:13]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 76639Benzyl isocyanateHCID 18699937HCID 18699937, compound

Product 1

HCID 18699950HCID 18699950, compoundYield 98.7%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

0.14 ml (1.1 mmol) of benzyl isocyanate was added to 20 ml of pyridine solution containing 278 mg (1.0 mmol) of the compound of Example 43, and the mixture was stirred at room temperature for 24 hours. The reaction solution was concentrated under a reduced pressure, and the resulting residue was subjected to a silica gel column chromatography, which was eluted with chloroform-methanol (50:1) to give 406 mg of the title compound.

Workup

  1. concentrationThe reaction solution was concentrated under a reduced pressure
  2. washwas eluted with chloroform-methanol (50:1)

Sources & evidence

ORD record
ord-a5250fccb643436bb7ac8755ee4007cc
Source dataset
uspto-grants-2000_07
Patent number
US06090804

Reaction notes

Loading…