Ethyl 2-((tert-butoxycarbonyl)amino)acetate → HCID 18699961, compound

HRID 2288611Notes

Reaction equation

HRID 2288611 reaction equation
[N:1]1([CH2:8][C:9]2[S:13][C:12]([C:14](=[N:16][OH:17])[NH2:15])=[CH:11][CH:10]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(O[C:21](=O)[CH2:22][NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])C>>[C:27]([O:26][C:24]([NH:23][CH2:22][C:21]1[O:17][N:16]=[C:14]([C:12]2[S:13][C:9]([CH2:8][N:1]3[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)=[CH:10][CH:11]=2)[N:15]=1)=[O:25])([CH3:30])([CH3:29])[CH3:28]

Participants

3

Reactant 2

HCID 357729Ethyl 2-((tert-butoxycarbonyl)amino)acetateHCID 54193930HCID 54193930, compound

Product 1

HCID 18699961HCID 18699961, compoundYield 41.8%

Procedure

Using 1.7 g of 5-(hexahydro-1H-azepin-1-yl)methyl-2-thiopheneamidoxime and 2.0 g of N-t-butoxycarbonylglycine ethyl ester, 1.1 g of the title compound was obtained in the same manner as described in the step 1) of Example 56.

Sources & evidence

ORD record
ord-ec9b08c139d64ba18eb97fdd37e600e3
Source dataset
uspto-grants-2000_07
Patent number
US06090804

Reaction notes

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