HCID 18699961, compound → HCID 86755525, compound

HRID 2288612Notes

Reaction equation

HRID 2288612 reaction equation
C(OC([NH:8][CH2:9][C:10]1[O:14][N:13]=[C:12]([C:15]2[S:19][C:18]([CH2:20][N:21]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:17][CH:16]=2)[N:11]=1)=O)(C)(C)C.[ClH:28].O1CCOCC1>>[ClH:28].[ClH:28].[NH2:8][CH2:9][C:10]1[O:14][N:13]=[C:12]([C:15]2[S:19][C:18]([CH2:20][N:21]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:17][CH:16]=2)[N:11]=1

Participants

3

Reactant 2

HCID 18699961HCID 18699961, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 86755525HCID 86755525, compound

Procedure

1.1 g of 1-[5-(5-t-butoxycarbonylaminomethyl-1,2,4-oxadiazol-3-yl)-2-thenyl]hexahydro-1H-azepine was dissolved in 30 ml of 4 N hydrochloric acid-1,4-dioxane solution, and the solution was stirred at room temperature for 30 minutes. The reaction solution was concentrated under a reduced pressure, and the resulting residue was recrystallized from ethyl acetate to give 966 mg of the title compound.

Workup

  1. concentrationThe reaction solution was concentrated under a reduced pressure
  2. customthe resulting residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-59a900f9084d4b6c8d2d166bbdce97f8
Source dataset
uspto-grants-2000_07
Patent number
US06090804

Reaction notes

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