HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 6-Amino-1-(3-chlorobenzyl)-uracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1-(3-Chlorobenzyl)-3-cyanoacetyl-urea | HCID 18432835 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 6-Amino-1-(3-chlorobenzyl)-uracil | HCID 1526619 | 89.2% |
Reaction Steps
A suspension of 10.17 g (40.4 mM) of 1-(3-chlorobenzyl)-3-cyanoacetyl-urea in 80 ml of 2-propanol was added to a solution of 5.7 g KOH in 40 ml of 2-propanol and heated under reflux for 1 hour. After cooling the solid was collected and washed to give the crude title compound (9.07 g) as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06090816 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-bfd59b8bca894a9993587219c17502a8 |
| Source note | uspto-grants-2000_07 |