Benzoyl Peroxide → HCID 18700307, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3 g of N-tert-butyl-4-methyl-3-methoxybenzamide, 2.4 g of N-bromosuccinimide, 0.16 g of benzoyl peroxide in 40 ml of carbon tetrachloride is stirred at 30° C., under irradiation with visible light for 48 hours. The solvent is evaporated off, then in succession 25 ml of water is added, the mixture is extracted with diethyl ether, dried over magnesium sulfate, the solvent is evaporated off and the residue is chromatographed on silica gel, eluting with an 8/2 cyclohexane/ethyl acetate (v/v) mixture. The expected reactant is isolated after crystallisation from isopropyl ether; M.p.=114° C.

Provenance & Evidence