1-(4-Pyridinyl)-4-piperidinecarbonyl chloride → HCID 22721768, compound

HRID 2288726Notes

Reaction equation

HRID 2288726 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([C:13](Cl)=[O:14])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[N:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22]1[CH:27]=[CH:26][C:25]([S:28]([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)(=[O:30])=[O:29])=[CH:24][CH:23]=1>>[N:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22]1[CH:23]=[CH:24][C:25]([S:28]([N:31]2[CH2:32][CH2:33][N:34]([C:13]([CH:10]3[CH2:11][CH2:12][N:7]([C:4]4[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=4)[CH2:8][CH2:9]3)=[O:14])[CH2:35][CH2:36]2)(=[O:30])=[O:29])=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 111837001-(4-Pyridinyl)-4-piperidinecarbonyl chlorideHCID 22721783HCID 22721783, compound

Product 1

HCID 22721768HCID 22721768, compoundYield 54%

Procedure

Using an analogous procedure to that described in Example 1, 1-(4-pyridyl)piperidine-4-carbonyl chloride was reacted with 1-[4-(2-pyridyl)phenylsulphonyl]piperazine to give 1-[4-(2-pyridyl)phenyl-sulphonyl]4-[1(4-pyridyl)piperidine-4-ylcarbonyl]piperazine in 54% yield, m.p. 224-226° C.;

Sources & evidence

ORD record
ord-57ae8b2aca314f9f86322cfa9e220294
Source dataset
uspto-grants-2000_07
Patent number
US06090813

Reaction notes

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