Sodium Hydroxide → 1-N-Cbz-pyrrolidine-3-carboxylic acid

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Reaction Steps

Aqueous 1M NaOH (6 ml) was added to a stirred solution of the above ester (1.37 g) in MeOH (6 ml). After 1 hour, the methanol was evaporated. H2O (20 ml) was added to the residue and 1M HCl (6 ml) was added dropwise to the stirred mixture. This aqueous phase was extracted with EtOAc (3×25 ml). The combined organic phases were washed with saturated brine (1×20 ml) dried and evaporated to give, as a colourless oil, N-Cbz-3-carboxy pyrrolidine (780 mg);

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