Sulfuric Acid → HCID 178448759, compound

Participants

Reaction Steps

The compound of Example 26 was treated with catalytic sulfuric acid in wet acetone at reflux. Purification gave 5-[2-[5-[[1-butyl-3-formyl-1H-1,2,4-triazol-5-yl]methyl]-2-pyridinyl)phenyl]-1H-tetrazole as a colorless solid: mp 167-168° C.; NMR (CDCl3) δ 0.94 (t, J=7 Hz, 3H), 1.35 (m, J=7 Hz, 2H), 1.88 (m, J=7 Hz, 2H), 4.22 (t, J=7 Hz, 2H), 4.29 (s, 2H), 7.37 (d, J=8 Hz, 1H), 7.46-7.55 (m, 3H), 7.44 (dd, J=8 and 2 Hz, 1H), 7.93-7.99 (m, 1H), 8.59 (d, J=2 Hz, 1H), 9.95 (s, 1H); MS(FAB) m/e (rel intensity) 389(100), 361(66), 346(26), 333(24), 305(17), 290(23); HRMS. Calc'd. for M+H: 389.1838. Found: 389.1829.

Provenance & Evidence