Methyl 2-(2-hvdroxyethyl)indole-5-acetate → 2-(2-(3-Phenyl-7-propylbenz[4,5]isoxazol-6-yloxy)ethyl) indole-5-acetic acid

HRID 2288875Notes

Reaction equation

HRID 2288875 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[NH:5][C:6]2[C:11]([CH:12]=1)=[CH:10][C:9]([CH2:13][C:14]([O:16]C)=[O:15])=[CH:8][CH:7]=2.[C:18]1([C:24]2[C:28]3[CH:29]=[CH:30][C:31](O)=[C:32]([CH2:33][CH2:34][CH3:35])[C:27]=3[O:26][N:25]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:18]1([C:24]2[C:28]3[CH:29]=[CH:30][C:31]([O:1][CH2:2][CH2:3][C:4]4[NH:5][C:6]5[C:11]([CH:12]=4)=[CH:10][C:9]([CH2:13][C:14]([OH:16])=[O:15])=[CH:8][CH:7]=5)=[C:32]([CH2:33][CH2:34][CH3:35])[C:27]=3[O:26][N:25]=2)[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 15462903Methyl 2-(2-hvdroxyethyl)indole-5-acetateHCID 1358008113-phenyl-7-propyl-1,2-Benzisoxazol-6-ol

Product 1

HCID 154857452-(2-(3-Phenyl-7-propylbenz[4,5]isoxazol-6-yloxy)ethyl) indole-5-acetic acid

Procedure

Using the procedures in Example 1, steps F and G, the title compound was prepared from methyl 2-(2-hydroxyethyl)indole-5-acetate and 3-phenyl-7-propyl-6-hydroxybenz[4,5]isoxazole as a colorless gum.

Sources & evidence

ORD record
ord-6fa8045b0b27466a9f0904baa31f15ef
Source dataset
uspto-grants-2000_07
Patent number
US06090839

Reaction notes

Loading…