Methyl 2-(2-hvdroxyethyl)indole-5-acetate → 2-(2-(3-(2-Phenyl)ethyl-7-propylbenz[4,5]isoxazol-6-yloxy)ethyl)indole-5-acetic acid

HRID 2288877Notes

Reaction equation

HRID 2288877 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[NH:5][C:6]2[C:11]([CH:12]=1)=[CH:10][C:9]([CH2:13][C:14]([O:16]C)=[O:15])=[CH:8][CH:7]=2.[C:18]1([CH2:24][CH2:25][C:26]2[C:30]3[CH:31]=[CH:32][C:33](O)=[C:34]([CH2:35][CH2:36][CH3:37])[C:29]=3[O:28][N:27]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:18]1([CH2:24][CH2:25][C:26]2[C:30]3[CH:31]=[CH:32][C:33]([O:1][CH2:2][CH2:3][C:4]4[NH:5][C:6]5[C:11]([CH:12]=4)=[CH:10][C:9]([CH2:13][C:14]([OH:16])=[O:15])=[CH:8][CH:7]=5)=[C:34]([CH2:35][CH2:36][CH3:37])[C:29]=3[O:28][N:27]=2)[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 15462903Methyl 2-(2-hvdroxyethyl)indole-5-acetateHCID 1363336723-(2-Phenyl)ethyl-7-(n-propyl)-6-hydroxybenz[4,5]isoxazole

Product 1

HCID 154857462-(2-(3-(2-Phenyl)ethyl-7-propylbenz[4,5]isoxazol-6-yloxy)ethyl)indole-5-acetic acid

Procedure

Using the procedures in Example 1, steps F and G, the title compound was prepared from methyl 2-(2-hydroxyethyl)indole-5-acetate and 3-(2-phenyl)ethyl-7-(n-propyl)-6-hydroxybenz[4,5]isoxazole as a slightly tan solid.

Sources & evidence

ORD record
ord-67a3625797924d8aa677d57f9081bbbf
Source dataset
uspto-grants-2000_07
Patent number
US06090839

Reaction notes

Loading…