Methyl 2-(2-hvdroxyethyl)indole-5-acetate → 2-(2-(4-(4-Trifluoromethylphenoxy)-2-propylphenoxy)ethyl)indole-5-acetic acid

HRID 2288888Notes

Reaction equation

HRID 2288888 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[NH:5][C:6]2[C:11]([CH:12]=1)=[CH:10][C:9]([CH2:13][C:14]([O:16]C)=[O:15])=[CH:8][CH:7]=2.[F:18][C:19]([F:38])([F:37])[C:20]1[CH:36]=[CH:35][C:23]([O:24][C:25]2[CH:30]=[CH:29][C:28](O)=[C:27]([CH2:32][CH2:33][CH3:34])[CH:26]=2)=[CH:22][CH:21]=1>>[F:18][C:19]([F:37])([F:38])[C:20]1[CH:36]=[CH:35][C:23]([O:24][C:25]2[CH:30]=[CH:29][C:28]([O:1][CH2:2][CH2:3][C:4]3[NH:5][C:6]4[C:11]([CH:12]=3)=[CH:10][C:9]([CH2:13][C:14]([OH:16])=[O:15])=[CH:8][CH:7]=4)=[C:27]([CH2:32][CH2:33][CH3:34])[CH:26]=2)=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 15462903Methyl 2-(2-hvdroxyethyl)indole-5-acetateHCID 186724954-(4-Trifluoromethylphenoxy)-2-propylphenol

Product 1

HCID 154857522-(2-(4-(4-Trifluoromethylphenoxy)-2-propylphenoxy)ethyl)indole-5-acetic acid

Procedure

Using the procedures in Example 15, steps F and G, the title compound was prepared from methyl 2-(2-hydroxyethyl)indole-5-acetate and 4-(4-trifluoromethylphenoxy)-2-propylphenol.

Sources & evidence

ORD record
ord-d9db90a7464045218c18316f1ee8c7a2
Source dataset
uspto-grants-2000_07
Patent number
US06090839

Reaction notes

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