Formamide → HCID 178486775, compound

HRID 228889Notes

Reaction equation

HRID 228889 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]([CH3:12])[C:9]([O:13][CH3:14])=[CH:8][C:3]=1[C:4](OC)=[O:5].[CH:15]([NH2:17])=O>>[CH3:14][O:13][C:9]1[CH:8]=[C:3]2[C:2](=[CH:11][C:10]=1[CH3:12])[NH:1][CH:15]=[N:17][C:4]2=[O:5]

Participants

3

Reactant 2

HCID 713FormamideHCID 20281748HCID 20281748, compound

Product 1

HCID 178486775HCID 178486775, compoundYield 55%

Conditions

Temperature
140 °C

Procedure

Methyl 2-amino-5-methoxy-4-methylbenzoate (510 mg) was suspended in formamide (5 ml), and the suspension was stirred at 140° C. overnight. The precipitated crystal was washed with ether to give 6-methoxy-7-methyl-1H-quinazolin-4-one (275 mg, yield 55%).

Workup

  1. washThe precipitated crystal was washed with ether

Sources & evidence

ORD record
ord-002bd8c27f274754bb1c123fbbcde5d8
Source dataset
uspto-grants-2009_07
Patent number
US07560558B2

Reaction notes

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