Sodium Hydroxide → Sodium 3-((5-oxo-1-{3-((N-phenylcarbamoyl)amino)phenyl}pyrrolidin-3-yl)carbonylamino)-3-(3-pyridyl)propanoate

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A solution of ethyl 3-((5-oxo-1-{3-((N-phenylcarbamoyl)amino)phenyl}pyrrolidin-3-yl)carbonylamino)-3-(3-pyridyl)propanoate (75 mg, 0.14 mmol, 1.0 eq), THF (1.0 mL), and 1.0 N NaOH (0.15 mL, 1.1 eq) was stirred at room temperature overnight. The solvent was removed on rotary evaporator. The title compound was obtained as an off-white solid. 1H NMR (MeOH-d4, 400 MHz): δ 2.77 (m, 4), 3.30 (m, 1, overlap with solvent), 4.08 (m, 2), 5.35 (m, 1), 7.01(m, 2), 7.28 (m, 4), 7.41(m, 3), 7.66 (m, 1), 7.86 (m, 1), 8.39 (m, 1), 8.57 (m, 1). MS (ES+): 488 (M+H)+; (ES−): 486 (M−H)−.

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