Ethanethiol → HCID 15888333, compound

HRID 2288913Notes

Reaction equation

HRID 2288913 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH:21]4[CH2:26][CH2:25][CH2:24][CH2:23][O:22]4)=[CH:15][CH:14]=3)=[O:12])=[C:9]([C:27]3[CH:32]=[CH:31][C:30]([O:33]C)=[CH:29][CH:28]=3)[S:8][C:7]=2[CH:35]=1.C(S)C.[Cl-].[Al+3].[Cl-].[Cl-]>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:14]=[CH:15][C:16]([O:19][CH2:20][CH:21]4[CH2:26][CH2:25][CH2:24][CH2:23][O:22]4)=[CH:17][CH:18]=3)=[O:12])=[C:9]([C:27]3[CH:28]=[CH:29][C:30]([OH:33])=[CH:31][CH:32]=3)[S:8][C:7]=2[CH:35]=1

Participants

4

Reactant 3

HCID 6343EthanethiolHCID 6451240Aluminum(III) ChlorideHCID 15888332HCID 15888332, compound

Product 1

HCID 15888333HCID 15888333, compoundYield 62%

Procedure

[6-Methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][4-(tetrahydropyran-2-yl)methoxyphenyl]methanone (0.32 g, 0.66 mmol) was converted to the title compound by the procedure of Example 3 using 0.24 mL (3.31 mmol) of ethanethiol and 530 mg (3.97 mmol) of aluminum chloride.

Sources & evidence

ORD record
ord-c252f8bca7c140df8c875d52c13c5343
Source dataset
uspto-grants-2000_07
Patent number
US06090843

Reaction notes

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