Ethanethiol → HCID 21702000, compound

HRID 2288920Notes

Reaction equation

HRID 2288920 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH:21]([O:30]C)[CH2:22][NH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]C)=[CH:15][CH:14]=3)=[O:12])=[C:9]([C:32]3[CH:37]=[CH:36][C:35]([O:38]C)=[CH:34][CH:33]=3)[S:8][C:7]=2[CH:40]=1.C(S)C.[Cl-].[Al+3].[Cl-].[Cl-]>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:14]=[CH:15][C:16]([O:19][CH2:20][CH:21]([OH:30])[CH2:22][NH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:17][CH:18]=3)=[O:12])=[C:9]([C:32]3[CH:33]=[CH:34][C:35]([OH:38])=[CH:36][CH:37]=3)[S:8][C:7]=2[CH:40]=1

Participants

4

Reactant 3

HCID 6343EthanethiolHCID 6451240Aluminum(III) ChlorideHCID 21702023HCID 21702023, compound

Product 1

HCID 21702000HCID 21702000, compoundYield 63.8%

Procedure

[6-Methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][4-(2-methoxy-3-hexylaminopropoxy)phenyl]methanone (340 mg, 0.62 mmol) was converted to 200 mg of the title compound by the procedure of Example 32 using 0.23 mL (3.1 mmol) of ethanethiol 660 mg (5.0 mmol) of aluminum chloride.

Sources & evidence

ORD record
ord-213f4c1260da491e98f78f4a22e4ff35
Source dataset
uspto-grants-2000_07
Patent number
US06090843

Reaction notes

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