N2 (tert-butoxycarbonyl)-N5-cyano-L-ornithine tert-butyl ester → HCID 178475097, compound

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Reaction Steps

By the method described above for the preparation of N2 -(tert-butoxycarbonyl)-N5 -(iminomethoxymethyl)-L-ornithine tert-butyl ester hydrochloride, 1.05 g (3.35 mmol) of N2 -(tert-butoxycarbonyl)-N5 -cyano-L-ornithine tert-butyl ester produced 0.95 g (75%) N2 -(tert-butoxycarbonyl)-N5 -(ethoxyiminomethyl)-L-ornithine tert-butyl ester hydrochloride (TLC, silica gel, methanol:dichloromethane/1:4, Rf=0.61) and 1.195 g (3.2 mmol) of N2 -(tert-butoxycarbonyl)-N5 -cyano-L-ornithine tert-butyl ester produced 0.63 g (63%) N2 -(tert-butoxycarbonyl)-N5 -(iminoisopropoxymethyl)-L-ornithine tert-butyl ester hydrochloride (TLC, silica gel, methanol: dichloro methane/1:4, Rf=0.53). Mass Spectrum (CI) 360 (MH+, 100%).

Provenance & Evidence