Water → HCID 18700447, compound

Participants

Reaction Steps

A suspension of 1-acetyl-piperidine-4-carboxylic acid (2-oxo-2-phenyl-ethyl)-amide (1.1 g, 3.8 mmol), prepared as in Part A, in conc. H2SO4 (20 mL) is warmed to 65° C. for 1 h. The warm solution is poured into H2O (250 mL), which is neutralized with solid NaHCO3. This solution is extracted with EtOAc (2×200 mL) and the combined organic extracts are dried (MgSO4) and concentrated to afford 1-[4-(5-phenyl-oxazol-2-yl)-piperidin-1-yl]-ethanone as a clear oil.

Provenance & Evidence