反应详情

To a 500 ml three neck flask fitted with mechanical stirrer under nitrogen is added 2,4-difluorobenzoyl chloride (141 mmol, 25 g), methyl isocyanoacetate (143 mmol, 13 mL), triethylamine (424 mmol, 60 mL) and tetrahydrofuran (200 mL). The mixture is stirred for 72 hours at room temperature. The reaction is concentrated to a thick slurry and then transferred to a separatory funnel using 500 mls of distilled water. The aqueous mixture is extracted with ethyl acetate (4×250 mL). The ethyl acetate washes are combined and washed with brine. The organics are dried over anhydrous magnesium sulfate and concentrated in vacuo. The resulting residue is disolved in hot ethanol (400 mL) and treated with decolorizing carbon and magnesium sulfate. After 15 minutes, the mixture is filtered to remove the insolubles. To the filtrate is added to one liter of distilled water. A precipitate forms and the resultant mixture is allowed to stand. The resulting solid is collected by filtration and is washed with copious amounts of water. The resulting solid is dried under vacuum to give the title compound.

1. concentrationThe reaction is concentrated to a thick slurry
2. customtransferred to a separatory funnel
3. extractionThe aqueous mixture is extracted with ethyl acetate (4×250 mL)
4. washwashed with brine
5. dry with materialThe organics are dried over anhydrous magnesium sulfate
6. concentrationconcentrated in vacuo
7. additiontreated with decolorizing carbon and magnesium sulfate
8. waitAfter 15 minutes
9. filtrationthe mixture is filtered
10. customto remove the insolubles
11. additionTo the filtrate is added to one liter of distilled water
12. filtrationThe resulting solid is collected by filtration
13. washis washed with copious amounts of water
14. customThe resulting solid is dried under vacuum