1,1'-Carbonyldiimidazole → HCID 57047864, compound

Participants

Reaction Steps

To a solution of 4-hydroxy-1-(4-nitrobenzyloxycarbonyl)-L-proline (1.79 g) in anhydrous acetonitrile (30 ml), N,N,-carbonyldiimidazole (981 mg) was added at room temperature, followed by stirring at room temperature for one hour. To the reaction mixture, a solution of (3S)-3-amino-1-(tert-butoxycarbonyl)pyrrolidine (1.02 g) in anhydrous acetonitrile (20 ml) was added under ice cooling. The resulting mixture was stirred at room temperature for 6 hours. The reaction mixture was purified in a similar manner to that described in Referential Example 1-(1), whereby 1.22 g of (3S)-1-(tert-butoxycarbonyl)-3-[1-(4-nitrobenzyloxycarbonyl)-4-hydroxy-L-prolylamino]pyrrolidine were obtained as an amorphous substance.

Provenance & Evidence