1,1'-Carbonyldiimidazole → HCID 57040603, compound

Participants

Reaction Steps

To a solution of 1-(4-nitrobenzyloxycarbonyl)-2-piperidinecarboxylic acid (1.54 g) in anhydrous acetonitrile (30 ml), N,N-carbonyldiimidazole (851 mg) was added at the room temperature, followed by stirring for one hour. The reaction mixture was allowed to react with a solution of (3S)-3-amino-1-(tert-butoxycarbonyl)pyrrolidine (931 mg) in anhydrous acetonitrile (15 ml) under ice cooling in a similar manner to that described in Referential Example 1-(1), whereby 1.81 g of (3S)-1-(tert-butoxycarbonyl)-3-[1-(4-nitrobenzyloxycarbonyl)piperidin-2-ylcarbonylamino]pyrrolidine were obtained as a colorless amorphous substance.

Provenance & Evidence