1,1'-Carbonyldiimidazole → HCID 54375516, compound

Participants

Reaction Steps

To a solution of 1-(4-nitrobenzyloxycarbonyl)-L-proline (2.81 g) in anhydrous acetonitrile (40 ml), N,N-carbonyldiimidazole (1.42 g) was added at room temperature, followed by stirring for one hour. The reaction mixture was allowed to react under ice cooling with a solution of 3-amino-1-(tert-butoxycarbonyl)azetidine (1.31 g) in anhydrous acetonitrile (10 ml) in a similar manner to that described in Referential Example 1-(1), whereby 2.74 g of 1-(tert-butoxycarbonyl)-3-[1-(4-nitrobenzyloxycarbonyl)-L-prolylamino]azetidine were obtained.

Provenance & Evidence