(2S,4S)-4-(4-methoxybenzyl)thio-1-(4-nitrobenzyloxycarbonyl)-L-proline → HCID 57039342, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (2S,4S)-4-(4-methoxybenzyl)thio-1-(4-nitrobenzyloxycarbonyl)-L-proline (1.47 g) in anhydrous tetrahydrofuran (30 ml), N,N'-carbonyldiimidazole (0.59 g) was added, followed by stirring at 30° C. for one hour. To the reaction mixture, a solution of (3S)-3-[(3S,4S)-5-cyclohexyl-3-hydroxy-4-(4-nitrobenzyloxycarbonyl)aminopentanoylamino]pyrrolidine (1.38 g) in anhydrous tetrahydrofuran (30 ml) was added. The reaction mixture was treated in a similar manner to that described in Referential Example 18-(1), whereby 2.43 g of the title target compound were obtained as an amorphous substance.

Provenance & Evidence