(2S,4S)-4-(4-methoxybenzyl)thio-1-(4-nitrobenzyloxycarbonyl)-L-proline → HCID 86755550, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (2S,4S)-4-(4-methoxybenzyl)thio-1-(4-nitrobenzyloxycarbonyl)-L-proline (2.23 g) in anhydrous tetrahydrofuran (50 ml), N,N'-carbonyldiimidazole (0.97 g) was added, followed by stirring at 30° C. for 30 minutes. To the reaction mixture, a solution of (3S)-3-[(3R,4S)-3-hydroxy-4-(4-nitrobenzyloxycarbonyl)amino-5-phenylpentanoylamino]pyrrolidine (2.28 g) in anhydrous tetrahydrofuran (50 ml) was added. The resulting mixture was treated in a similar manner to that described in Referential Example 18-(1), whereby 2.14 g of the title compound were obtained as a powder.

Provenance & Evidence