Tetrahydrofuran → Diisopropylethylamine

Participants

Reaction Steps

To a solution of (2S,4S)-4-(4-methoxybenzyl)thio-1-(4-nitrobenzyloxycarbonyl)-L-proline (1.28 g) in anhydrous acetonitrile (19 ml), N,N'-carbonyldiimidazole (489 mg) was added, followed by stirring at room temperature for one hour. To the reaction mixture, N,N-diisopropylethylamine (478 μl) and a solution of the compound (2.60 g), which had been obtained in (1), in anhydrous tetrahydrofuran (15 ml ) were added. The resulting mixture was treated in a similar manner to that described in Referential Example 16-(3), whereby the title compound (2.09 g) was obtained as an amorphous substance.

Provenance & Evidence