Acetic Anhydride → HCID 136005304, compound

HRID 2289085Notes

Reaction equation

HRID 2289085 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:28][C:29]([O:31][CH3:32])=[O:30])[CH:5]=[CH:6][C:7]=1[S:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[N:22][OH:23])[CH2:20][CH3:21])=[C:15]([OH:24])[C:14]=1[CH2:25][CH2:26][CH3:27].[C:33](OC(=O)C)(=[O:35])[CH3:34]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:28][C:29]([O:31][CH3:32])=[O:30])[CH:5]=[CH:6][C:7]=1[S:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[N:22][O:23][C:33](=[O:35])[CH3:34])[CH2:20][CH3:21])=[C:15]([OH:24])[C:14]=1[CH2:25][CH2:26][CH3:27]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 136333674HCID 136333674, compound

Product 1

HCID 136005304HCID 136005304, compound

Procedure

A solution of methyl 3-chloro-4-(3-(2-propyl-3-hydroxy-4-(1-hydroxyiminopropyl)phenoxy)propylthio)phenyl acetate (Step C; 5.96 grams) in acetic anhydride (50 mL) was stirred for 16 hours. The solvent was removed in vacuo. The remaining residue was dissolved in isopropyl acetate and washed with pH 7 buffer. The organic phase was dried over magnesium sulfate, filtered and evaporated. The title compound was used without further purification.

Workup

  1. customThe solvent was removed in vacuo
  2. dissolutionThe remaining residue was dissolved in isopropyl acetate
  3. washwashed with pH 7 buffer
  4. dry with materialThe organic phase was dried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated
  7. customThe title compound was used without further purification

Sources & evidence

ORD record
ord-16f0931d5a6c45edba81f783c5a8dc4f
Source dataset
uspto-grants-2000_07
Patent number
US06090836

Reaction notes

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