HCID 136005304, compound → HCID 15887296, compound

Participants

Reaction Steps

A solution of methyl 3-chloro-4-(3-(2-propyl-3-hydroxy-4-(1-acetoxyiminopropyl)phenoxy)propylthio)phenylacetate (Step D; 6.19 grams) in dry pyridine (65 mL) was refluxed for 3 hours. The solvent was removed in vacuo and the residue partitioned between isopropyl acetate and 0.1N HCl. The organic was washed once more with 0.1N HCl. The organic was dried over magnesium sulfate, filtered and evaporated to an oil. The crude product was placed on a slica gel column and eluted with hexane/CH2Cl2 (1:1) until the product appeared in the eluant. The mobile phase was changed to 100% CH2Cl2 and elution continued until all the title compound was recovered.

Provenance & Evidence