Methyl iodide → HCID 69967351, compound

Participants

Reaction Steps

A solution of 3-hydroxy-6-benzyloxy-7-propylbenz-[4,5]-isoxazole (Step C; 195 mg) in acetone (3 mL) was treated with methyl iodide (0.067 mL) and potassium carbonate (100 mg). The mixture was refluxed for 8 hours. The reaction was partitioned between isopropyl acetate and pH 4 buffer. The organic was dried over magnesium sulfate, filtered and concentrated to a solid, which was chromatographed over silica gel to afford the title compound.

Provenance & Evidence