Methanesulfonic Acid → HCID 136131617, compound

Participants

Reaction Conditions

Reaction Steps

1-[2-(7-Benzyloxy-6-methoxy-quinolin-4-yloxy)-4,5-dimethyl-phenyl]-ethanone (compound 313) (1.10 g) was suspended in a mixed solution composed of methanesulfonic acid (0.8 ml) and trifluoroacetic acid (10 ml), and the mixture was stirred at 70° C. for one hr. The solvent was removed by distillation under the reduced pressure, water was added to the residue, and the mixture was neutralized with sodium hydrogencarbonate powder and was then extracted with chloroform. Next, the chloroform layer was washed with water and saturated brine and was dried over anhydrous magnesium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by column chromatography using chloroform-methanol to give the title compound (700 mg, yield 83%).

Provenance & Evidence