HCID 56988678, compound → 2-propylbenzene-1,4-diol

HRID 2289108Notes

Reaction equation

HRID 2289108 reaction equation
[CH:1]([C:4]1[CH:9]=[C:8]([O:10]CC2C=CC=CC=2)[CH:7]=[CH:6][C:5]=1[OH:18])=[CH:2][CH3:3]>CO.[Pd]>[CH2:1]([C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[CH:6][C:5]=1[OH:18])[CH2:2][CH3:3]

Participants

4

Reactant 1

HCID 56988678HCID 56988678, compound

Product 1

HCID 99204292-propylbenzene-1,4-diol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

6.8 grams (28.4 mmole, 1.0 eq.) of product from step B was dissolved in 60 ml of methanol. 680 mg of 10% palladium on carbon (0.64 mmole, 0.023 eq.) was added and the stirring suspension was evacuated and charged with hydrogen. After 16 hours the catalyst was filtered over celite and the filtrate evaporated. The title compound (4.3 grams) was recovered by recrystallization from dichloromethane/hexanes.

Workup

  1. customthe stirring suspension was evacuated
  2. additioncharged with hydrogen
  3. filtrationAfter 16 hours the catalyst was filtered over celite
  4. customthe filtrate evaporated
  5. customThe title compound (4.3 grams) was recovered by recrystallization from dichloromethane/hexanes

Sources & evidence

ORD record
ord-4b2b796d0d754fdfac270763a8bb5c87
Source dataset
uspto-grants-2000_07
Patent number
US06090836

Reaction notes

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