HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → 4-(2-Chloro-ethoxy)-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Methylparaben | HCID 7456 | — |
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Product | 4-(2-Chloro-ethoxy)-benzoic acid methyl ester | HCID 6485431 | — |
Reaction Steps
4-hydroxybenzoic acid methyl ester (1.52 g, 10 mmol), anhydrous lithium carbonate (740 mg, 10 mmol), 15 ml of dimethylsulfoxide, and 15 ml of 1,2-dichloroethane are combined and heated to reflux. HPLC shows the reaction is at equilibrium at about 2 hours with a product to starting material ratio of 22.7:68.7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06090949 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-0378a2205f3945afaacfa11c920c8fbf |
| Source note | uspto-grants-2000_07 |