Triethylamine → HCID 53715106, compound

Participants

Reaction Steps

A mixture of 3-bromoquinoline 3-1(25 g, 120 mmol), acrylic acid tert-butyl ester (100 mL, 672 mmol), triethylamine (50 mL, 300 mmol) and Pd(OAc)2 (1.61 g, 7.2 mmol) in acetonitrile (100 mL) was refluxed for 18 hr. It is then cooled, diluted with 500 mL CH2Cl2 and filtered. The solution was washed with 10% NaHCO3, dried and concentrated. The residue was dissolved in 50 ml hot CH2Cl2 and diluted with 300 mL hexane. After standing, the desired product 3-2 was obtained as a crystalline compound.

Provenance & Evidence