HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl L-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | (-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid | HCID 2733226 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl L-1,2,3,4-tetrahydroisoquinoline-3-carboxylate | HCID 2760579 | — |
Reaction Steps
A mixture of 1 eq. of (S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid (Aldrich Chemical Co., Milwaukee, Wis.), 5 eq. of trimethylorthoformate, methanol and catalytic HCl were allowed to heat at reflux for 5 h. Concentration in vacuo provided methyl (S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06090950 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-79ad8340afd146e38ac4bd802f82877e |
| Source note | uspto-grants-2000_07 |