Acetic Acid → N-(2-cyano-3-methylbutanoyl)urea

Participants

Reaction Conditions

Reaction Steps

Cyanoacetylurea (38.7 g) was suspended in isopropanol (77.4 ml), and acetone (24.6 ml), acetic acid (3.43 ml) and ammonium acetate (2.31 g) were added. This suspension was subjected to catalytic hydrogenation in the presence of 10% palladium carbon (0.78 g, 50% wet product) under normal pressure at 30° C. for 8 hours. The reaction mixture was heated to 80° C. for 1 hour, and the catalyst was filtered off. Water (150 ml) was added to the filtrate to allow precipitation of crystals. The crystals were collected by filtration to give crystals of N-(2-cyano-3-methylbutanoyl)urea (yield 21.7 g).

Provenance & Evidence