HCID 135838121, compound → HCID 135838205, compound

Participants

Reaction Steps

A solution of 3-amino-9-vinylbenzo[f]quinazolin-1(2H)-one (0.060 g, 0.25 mmol) and 10% palladium on carbon (0.10 g) (Aldrich) in ethanol (200 ml) was shaken under hydrogen (40 psi) for 1 hour and then filtered through celite and concentrated in vacuo. The residue was suspended in ethanol, filtered, and dried at 850 C under reduced pressure to give 3-amino-9-ethylbenzo[f]-quinazolin-1(2H)-one (0.039 g) as a white solid. 1H NMR (DMSO-d6, 200 MHz) δ: 1.26 (t, J=7 Hz, 3H, CH3), 2.76 (q, J=7 Hz, 2H, CH2), 6.49 (br s, 2H, NH2), 7.21 (d, J=9 Hz, 1H, Ar), 7.31(dd, J=8, 2Hz, 1H, Ar), 7.77(d, J=8Hz, 1H Ar), 7.96 (d, J=9 Hz, 1H, Ar), 9.47 (s, 1H, Ar), 11.08 (br s, 1H, NH). Mass spectrum (CI-CH4): 240 (M+1, 100%). Anal. Calculated for C1-4H13N3 0 0.1H2O: C, 69.75; H, 5.52; N, 17.43. Found: C, 69.79; H, 5.53; N, 17.37.

Provenance & Evidence