Hydrochloric Acid → HCID 15840429, compound

Participants

Reaction Conditions

Reaction Steps

Into a stirred solution of 1-(1-(4-(1-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethyl)phenylacetyl)piperidin-4-yl)-4H-3,1-benzoxazin-2(1H)-one (0.35 g, 0.51 mmol) from Step 7 above in EtOAc (25 mL) at 0° C. was bubbled HCl gas for 15 min. The resulting suspension was stirred at 0° C. for 45 min. Excess HCl was removed by bubbling argon though the mixture for 15 min. The solvent was removed under reduced pressure and the residue was dissolved in CH2Cl2. The solvent was evaporated under reduced pressure to give the hydrochloride salt of the title compound as an amorphous solid.

Provenance & Evidence