反应详情

2-Trifluoromethoxyphenylacetonitrile (0.49 g, 2.6 mmol) from Step 3 above was refluxed for 3 h in a 1:1 mixture of acetic acid and concentrated aqueous HCl. The solvents were removed under reduced pressure. The residue was partitioned between EtOAc (75 mL) and water (2×25 mL). The organic phase was separated, dried (MgSO4), filtered, and evaporated under reduced pressure to give 2-trifluoromethoxyphenylacetic acid as an amorphous solid (HPLC retention time=6.8 min (method A)).

1. customThe solvents were removed under reduced pressure
2. customThe residue was partitioned between EtOAc (75 mL) and water (2×25 mL)
3. customThe organic phase was separated
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. customevaporated under reduced pressure