反应详情

2-(2,2,2-trifluoroethoxy)-3-chlorophenyl-acetonitrile (1.2 g, 5.1 mmol) from Step 3 above was refluxed in a 2:1 mixture of acetic acid and concentrated aqueous HCl (25 mL) for 12 h. The solvents were removed under reduced pressure and the residue was partitioned between EtOAc and water. The organic phase was washed with water, dried (MgSO4), filtered, and the solvent was removed under reduced pressure to give 2-(2,2,2-trifluoroethoxy)-3-chlorophenylacetic acid as an oil.

1. customThe solvents were removed under reduced pressure
2. customthe residue was partitioned between EtOAc and water
3. washThe organic phase was washed with water
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. customthe solvent was removed under reduced pressure