HCID 18700159, compound → HCID 18700079, compound

HRID 2289328Notes

Reaction equation

HRID 2289328 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[C:6]([O:11][CH2:12][C:13]([F:16])([F:15])[F:14])[CH:5]=1)([O-])=O.[H][H]>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[C:6]([O:11][CH2:12][C:13]([F:14])([F:15])[F:16])[CH:5]=1

Participants

5

Reactant 2

HCID 18700159HCID 18700159, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18700079HCID 18700079, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4-Nitro-2-(2,2,2-trifluoroethoxy)toluene (2.0 g, 9.0 mmol) from Step 1 above was dissolved in MeOH (20 mL) and shaken with palladium black (100 mg) under 50 psig of hydrogen on a Parr apparatus for 2 h. The catalyst was removed by filtration and the solvent was removed under reduced pressure to give 4-amino-2-(2,2,2-trifluoroethoxy)toluene as a gum.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-0aa5dcef2a0c43f2b9e91b88750d3c25
Source dataset
uspto-grants-2000_07
Patent number
US06090805

Reaction notes

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