3,4-dihydro-2H-pyran → HCID 15476080, compound

Participants

Reaction Steps

In a 50 ml egg-plant type flask were charged 1.7 g of 3,4-dihydro-2H-pyran, 30 ml of diethyl ether, 5.0 g of (2R,5S)-2-hydroxy-5-methylheptyl p-toluenesulfonate, and 50 mg of p-toluenesulfonic acid, and the mixture was stirred at room temperature overnight. The resulting reaction mixture was neutralized with a saturated sodium hydrogencarbonate aqueous solution, and diethyl ether was distilled off under reduced pressure to obtain 6.5 g of a crude product.

Provenance & Evidence