反应详情

In a flask were charged 15.89 g of (S)-3-methylpentanol and 65 ml of pyrimidine. After cooling to 0° to 50° C., 23.63 g of methanesulfonyl chloride was added thereto dropwise, and the mixture was allowed to react at the same temperature for 1 hour. The reaction mixture was extracted with diethyl ether, and the extract was washed with water and concentrated to obtain 12.14 g (46.42%) of the titled compound.

1. temperatureAfter cooling to 0° to 50° C.
2. customto react at the same temperature for 1 hour
3. extractionThe reaction mixture was extracted with diethyl ether
4. washthe extract was washed with water
5. concentrationconcentrated