Diazomethane → HCID 57194080, compound

Participants

Reaction Steps

A solution of 1.17 g of (2R,4S)-2-tetrahydropyranyloxy-4-caprylic acid obtained in Step 7 in 100 ml of diethyl ether was cooled to -50° C., and 200 ml of a diethyl ether solution of 75.68 mmol of diazomethane was poured thereinto. The mixture was stirred at room temperature for 1 hour, and diethyl ether was removed from the reaction mixture by distillation to obtain 2.12 g (100%) of the titled compound.

Provenance & Evidence