Methanesulfonyl chloride → HCID 88246547, compound

Participants

Reaction Steps

A mixture of 1.51 g of (2R,4S)-2-tetrahydropyranyloxy-4-methyloctanol obtained in Step 9 and 15 ml of pyridine was kept at -5° C., and 1.06 g of methanesulfonyl chloride was added thereto, followed by stirring at that temperature for 1 hour. The reaction mixture was poured into ice-water and extracted with diethyl ether. The extract was adjusted to pH 5 with 1% hydrochloric acid, washed with water, dried, and distilled to remove the solvent to obtain 1.74 g (77.81%) of the titled compound.

Provenance & Evidence