3,4-dihydro-2H-pyran → HCID 57144221, compound

Participants

Reaction Steps

In a 200 ml flask were charged 10 g of ethyl (2S,3S)-2-hydroxy-3-methylvalerate, 10.5 g of 3,4-dihydro-2H-pyran, 0.24 g of p-toluenesulfonic acid, and 100 ml of diethyl ether, and the mixture was allowed to react at room temperature overnight. The reaction mixture was neutralized with a sodium hydrogencarbonate aqueous solution, and diethyl ether was removed by distillation to obtain 6.15 g (49.7%) of a crude product.

Provenance & Evidence