HCID 57231691, compound → HCID 57026459, compound

Participants

Reaction Steps

In a 200 ml flask were charged 60 ml of methanol, 3.18 g of 10% palladium-on-carbon, and 10.6 g of t-butyl (3R,5S)-5-benzyloxy-3-fluorononanoate obtained in Step 4, and hydrogenolysis was conducted at room temperature for 8 hours. The catalyst was removed by filtration, and the filtrate was distilled to remove the solvent. The residue was purified by silica gel column chromatography to obtain 5.0 g (64.2%) of the titled compound.

Provenance & Evidence