Water → HCID 57222029, compound

Participants

Reaction Conditions

Reaction Steps

In a 100 ml flask were charged dried THF and 0.59 g of lithium aluminum hydride in a nitrogen stream, followed by cooling to 5° C. To the mixture was added dropwise a solution of 5.0 g of the compound obtained in Step 5 in 17 ml of dried THF over 20 minutes, followed by allowing the mixture to react at 35 to 40° C. for 3 hours. The reaction mixture was again cooled to 5° C., and a solution of 0.6 g of water and 2 ml of THF was added thereto over 30 minutes. Then, 1.6 ml of a 4% sodium hydroxide aqueous solution was added thereto, followed by stirring at that temperature for 1 hour.

Provenance & Evidence