Methanol → HCID 57062068, compound

Participants

Reaction Steps

In a 200 ml autoclave were charged 50 ml of methanol, 14.0 g of t-butyl (R)-5-methyl-3-oxononanoate obtained in Step 5, and a solution of 0.49 g of (S)-di[2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]tetrachlorodiruthenium triethylamine in 40 ml of methylene chloride, and the mixture was allowed to react under a hydrogen pressure of 60 kg/cm2 for 18 hours. The solvent was removed by distillation under reduced pressure to obtain 13.6 g of a crude product, which was then purified by silica gel column chromatography to obtain 10.3 g (72.5%) of the titled compound.

Provenance & Evidence