2,2,2-Trifluoroethyl trifluoromethanesulfonate → HCID 86755557, compound

HRID 2289397Notes

Reaction equation

HRID 2289397 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([S:11]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)(=[O:13])=[O:12])=[CH:10][C:5]=2[N:4]=[C:3]1[CH3:20].[F:21][C:22]([F:33])([F:32])[CH2:23][O:24][S:25]([C:28]([F:31])([F:30])[F:29])(=[O:27])=[O:26]>C1(C)C=CC=CC=1>[CH3:1][N+:2]1[C:6]2[CH:7]=[CH:8][C:9]([S:11]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)(=[O:12])=[O:13])=[CH:10][C:5]=2[N:4]([CH2:23][C:22]([F:33])([F:32])[F:21])[C:3]=1[CH3:20].[F:29][C:28]([F:31])([F:30])[S:25]([O-:27])(=[O:26])=[O:24]

Participants

4

Reactant 2

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 18697491HCID 18697491, compound

Product 1

HCID 86755557HCID 86755557, compoundYield 68.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In 20 ml of a toluene solution, 5.9 g of 1,2-dimethyl-5-morpholinosulfonylbenzimidazole synthesized by a method described in Japanese Patent Publication No. 43-10252, end 6.5 g of 2,2,2-trifluoroethyl-trifluoromethanesulfonate were heated in reflux for 24 hours. After the resulting mixture was allowed to cool to room temperature, the supernatant was separated; to the reaction mixture was added an ethyl acetate solution and dispersed, and the product was collected by filtration and washed to obtain 7.2 g of a quartenary salt.

Workup

  1. temperaturewere heated
  2. temperaturein reflux for 24 hours
  3. customthe supernatant was separated
  4. additionto the reaction mixture was added an ethyl acetate solution
  5. additiondispersed
  6. filtrationthe product was collected by filtration
  7. washwashed

Sources & evidence

ORD record
ord-a16917a024dc4293bb143f8433d5d88e
Source dataset
uspto-grants-2000_07
Patent number
US06093527

Reaction notes

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