反应详情

290 mg of isoquinoline-6-carbaldehyde are dissolved in 40 ml of MeON, and firstly 450 mg of NaCN, then 210 μl of glacial acetic acid, and finally 3.5 g of MnO2 are added. The mixture is stirred at RT for 3 days, and the precipitate is filtered off and the filtrate is poured into a solution of 15 g of FeSO4 in 150 ml of water. Subsequently, the pH of the mixture is adjusted to 9 with Na2CO3 solution, the precipitate is filtered off, and the filtrate is extracted 3× with 150 ml of EA. Drying takes place over Na2SO4, and the solvent is removed in vacuo. 190 mg are obtained of a colorless oil, which in reacted without any further purification.

1. filtrationthe precipitate is filtered off
2. additionthe filtrate is poured into a solution of 15 g of FeSO4 in 150 ml of water
3. filtrationthe precipitate is filtered off
4. extractionthe filtrate is extracted 3× with 150 ml of EA
5. customDrying
6. customthe solvent is removed in vacuo
7. custom190 mg are obtained of a colorless oil, which
8. customin reacted without any further purification