反应详情

1-Ethyl-4-piperidone (500 mg, 3.93 mmol) was mixed with 1-methyl-3,5-dinitro-2-pyridone (392 mg, 1.97 mmol) in 1M methanolic ammonia (40 mL,40 mmol) and heated at reflux for 3 h. The solvent was evaporated off and the residue was suspended in CHCl3 and flash chromatographed over silica gel (32 g)eluting with EtOAc to afford an orange solid (379 mg, 93% yield).

1. temperatureheated
2. temperatureat reflux for 3 h
3. customThe solvent was evaporated off
4. customflash chromatographed over silica gel (32 g)
5. washeluting with EtOAc